Adjuvant properties of poly (amidoamine) dendrimers

Details Adjuvant properties of poly (amidoamine) dendrimers Adjuvant properties of poly (amidoamine) dendrimers

1996-02-07

1998-08-18

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424 7817, 424DIG16, A61K 900, A61K 4748

Patent

active

057955824

ABSTRACT:
A new method of adjuvanting a variety of materials has been developed. Starburst dendrimers, primarily poly(amidoamine) starburst dendrimers, can be used as an adjuvant for Influenza antigen and similar materials. Mid-Generation dendrimers are preferred and yield high antibody titer levels with reduced antigen dosage.

REFERENCES:
patent: 4587329 (1986-05-01), Tomalia et al.
patent: 5338532 (1994-08-01), Tomalia et al.
patent: 5482698 (1996-01-01), Griffiths
International Search Report, PCT/US97/01664 dated Apr. 7, 1996.

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