Adipogenic differentiation of human mesenchymal stem cells

Details Adipogenic differentiation of human mesenchymal stem cells Adipogenic differentiation of human mesenchymal stem cells

1996-07-30

1998-10-27

Saunders, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435366, 435377, 435405, 514 46, 514171, 514261, 514263, 514415, 532 2, C12N 508, C07J 100, A61K 4500

Patent

active

058277404

ABSTRACT:
A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogenic lineage, and a process for inducing such differentiation. The composition for inducing such differentiation comprises a glucocorticoid and a compound which stimulates cAMP production or inhibits cAMP degradation (such as a phosphodiesterase inhibitor). The process can further include isolating the adipocytes from remaining hMSCs.

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DeFelici, M et al. CIBA Foundation Symposium. 182: 140-153, 1994.
Loffler, G et al. Klinische Wochenschrift. 65(17): 812-817, Sep. 1, 1987.

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