Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound other than saccharide containing a...
Patent
1994-05-02
1996-10-15
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound other than saccharide containing a...
4352523, 4353201, 514 2, 530350, 5303871, 5303873, 536 234, C07K 14705, C07K 1473, C07K 1400, C12N 1562
Patent
active
055653359
ABSTRACT:
Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into the adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.
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Haak-Frendscho et al., "Huma
Capon Daniel J.
Gregory Timothy J.
Genentech Inc.
Kubinec Jeffrey S.
Ulm John
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