Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-01-11
2011-01-11
Olson, Eric S (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C514S047000
Reexamination Certificate
active
07868163
ABSTRACT:
The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II). The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+.
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Basile Giovanna
Benatti Umberto
Bruzzone Santina
Damonte Gianluca
De Flora Antonio
Centro Biotecnologie Avanzate
Olson Eric S
Roylance, Abrams, Berdo & Goodman LLP.
Universita' Degli Studi Di Genova
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