Adenovirus vectors for gene therapy

Details Adenovirus vectors for gene therapy Adenovirus vectors for gene therapy

1995-10-06

1998-10-20

Chambers, Jasemine C.

Chemistry: molecular biology and microbiology

Vector, per se

514 44, 4351723, C12N 1500

Patent

active

058245448

ABSTRACT:
The present invention relates to novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replication-competent adenovirus (RCA) during in vitro propagation and clinical use. The invention also provides methods for the production of the novel virus vectors. These vectors maximize safety for clinical applications in which adenovirus vectors are used to transfer genes into recipient cells for gene therapy.

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