Adenosylmethionine synthetase from streptomyces sp. , gene...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide

Reexamination Certificate

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C435S193000, C435S069100, C435S320100, C435S252300, C435S252350, C435S253500

Reexamination Certificate

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07666631

ABSTRACT:
Disclosed is an isolated nucleotide sequence encoding an enzyme catalyzing biosynthesis of SAM (SAM-s) and its amino acid sequence. Also, the present invention provides a method for mass production of a useful secondary metabolite including antibiotics using the isolated nucleotide sequence and SAM, where SAM acts as a methyl group donor.

REFERENCES:
patent: 5712146 (1998-01-01), Khosla et al.
patent: 6312920 (2001-11-01), DeHoff et al.
patent: 09-224690 (1997-09-01), None
Merali, S. et al. “Continuous axenic cultivation ofPneumocystis carinii”, Proc.Natl.Acad.Sci. USA, vol. 96 pp. 2402-2407, 1999.

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