Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-11-07
2006-11-07
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S623000, C564S164000, C564S188000
Reexamination Certificate
active
07132457
ABSTRACT:
The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2or CH2CH2, E represents C(O)NH or NHC(O) and R3represents a group of formula (I).
REFERENCES:
patent: 3029241 (1962-04-01), Fancher et al.
patent: 3464998 (1969-09-01), Krimmel et al.
patent: 3732305 (1973-05-01), Bauer et al.
patent: 3789072 (1974-01-01), Bernstein
patent: 6201024 (2001-03-01), Baxter et al.
patent: 6242470 (2001-06-01), Baxter et al.
patent: 6258838 (2001-07-01), Baxter et al.
patent: 6303659 (2001-10-01), Baxter et al.
patent: 6492355 (2002-12-01), Alcaraz et al.
patent: 6555541 (2003-04-01), Furber et al.
patent: 6881754 (2005-04-01), Alcaraz et al.
patent: 0074768 (1983-03-01), None
patent: 0395093 (1990-10-01), None
patent: 0564924 (1993-10-01), None
patent: 0582164 (1994-02-01), None
patent: 2346011 (1977-10-01), None
patent: 95/04720 (1995-02-01), None
patent: 95/30647 (1995-11-01), None
patent: 95/32949 (1995-12-01), None
patent: 96/13262 (1996-05-01), None
patent: 97/32882 (1997-09-01), None
patent: 99/31096 (1999-06-01), None
patent: 99/29686 (1999-07-01), None
patent: 99/59582 (1999-11-01), None
patent: 00/61569 (2000-10-01), None
patent: 00/71529 (2000-11-01), None
patent: 01/42194 (2001-06-01), None
patent: 01/44213 (2001-06-01), None
patent: 01/46200 (2001-06-01), None
Billotte, “Synthesis of C-Substituted Cyclic Amines Using Azacycloalkyl Organozinc Reagents”, Syn. Lett., 1998, pp. 379-380.
Chemical Abstracts, vol. 57 (1962), Shin Hayao et al., “New sedative and hypotensive phenylpiperazine amides”, The Abstract No. 3443i, J. Org. Chem. 1961, 26, 3414-3419.
Chemical Abstracts, vol. 82, No. 3, Jan. 20, 1975, No et al., “Tetrakis(1-adamantyacetoxy)silane in organic synthesis”, Abstract No. 16510v. p. 469, Zh. Obshch. Kim. 1974, 44 (10), 2359.
Chemical Abstracts, vol. 84, No. 9, Mar. 1, 1976, p. 527, The Abstract No. 59466u, JP 75108264A (Maruyama, Isamu et al.) Aug. 26, 1975.
Chemical Abstracts, vol. 86, No. 17, Apr. 25, 1977, Danilenko et al., “Synthesis and biological activity of adamantane derivatives. V. Virus-inhibiting effect of arylamides of adamantanecarboxylic acids”, p. 505, Abstract No. 120855e, Khim.-Farmm.Zh. 1976, 10(7), pp. 60-62.
Liverton et al., “Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase”, J. Med. Chem., 1999, vol. 42, pp. 2180-2190.
Nomura et al., “Synthesis of Cyclic Imines Having Conjugated Exocyclic Double Bond”, Bull. Chem. Soc. Jpn., 1983, vol. 56, p. 3199-3120.
Palucki et al., “Palladium-Catalyzed Intermolecular Carbon-Oxygen Bond Formation: A New Synthesis of Aryl Ethers”, J. Am. Chem., 1997, vol. 199, pp. 3395-3396.
Smith et al., “Solid and Solution Phase Organic Syntheses of Oligomeric Thioureas”, J. Org. Chem, 1996, vol. 61, pp. 8811-8818.
Narayanan, “Adamantyl Analogs of 2-(3-Dimethylaminopropylthio)cinnamanilide”, Journal of Medicinal Chemistry, vol. 15, No. 11, pp. 1180-1182.
STN International, File CAPLUS, CAPLUS accession No. 1974:26871, Document No. 80:28671, Danilenko et al., “Synthesis and biological activity of adamantane derivatives. II. N-(1-Adamantoyl)anthranilic acids”, Kim.-Farm.Zh., 1973, 7(10), pp. 15-17.
STN International, File CAPLUS, CAPLUS accession No. 1975:592744, Document No. 83:192744, Kreutzberger et al., “Antiviral agents. 4. Aromatically substituted carbonic acid amide structure in potentially virustatic compounds”, Arzneim.-Forsch., 1975, 25(7) 994-997.
STN International, File CAPLUS, CAPLUS accession No. 1977:89560, Document No. 86:89560, Danilenko, G.I., et al., “Synthesis and biological activity of adamatane derivatives. VI. Antiinflammatory action of adamantylamides of pyridinecarboxylicacids”; Khim.-Famr.zh. (1976, 10(8), pp. 51-53.
STN International, File CAPLUS, CAPLUS accession No. 1991:656226, Document No. 115:256226, Kowa K.K., “Preparation of piperazine derivatives as antiarrhythmics”, & JP, A2, 19910617.
STN International, File CAPLUS, CAPLUS accession No. 1995:324637, Document No. 122:105919, Kyowa Hakko Kogyo KK: Preparation of quinazolinylpiperazineacetamide derivatives; & JP A2, 06247942, 19940906.
STN International, File CAPLUS, CAPLUS accession No. 1996:344490, Document No. 125:115117, Kalindjian et al., “The Synthesis of a radioligand with high potency and selectivity for CCKB/gastrain receptors”, Bioorg. Med. Chem. Lett. 1996, 6(10), pp. 1171-1174.
STN International, File CAPLUS, CAPLUS accession No. 1997:390174, Document No. 127:95591, Gibson et al., “Incorporation of conformationally constrained phenylalanine derivatives Tic, Sic, Hic and Nic into a cholecystokinin-b/gastrin receptor antagonist”, Bioorg. Med. Chem. Lett., 1997, 7(10), pp. 1289-1292.
STN International, File CAPLUS, CAPLUS accession No. 1968:402562, Document No. 69:2562, Sasaki et al., “Synthesis of adamantane derivatives II. Preparation of some derivatives from adamantylacetric acid”, Bull. Chem. Soc. Jap., 1968, 41(1), pp. 238-240.
STN International, File CAPLUS, CAPLUS accession No. 1975:3853, Document No. 82:3853, Kreutzberger et al., “Antiviral agents. 3. Aliphatic acid amide grouping as partial structure in virustatics”, Arch. Pham., 1974, 307(10), pp. 766-774.
Syamala et al., “Modification of Photochemical Reactivity by Cyclodextrin Complexation: Product Selectivity in Photo-Fries Rearrangement”, Tetrahedron, vol. 44, No. 23, 1998, pp. 7234-7242.
Tsunoda et al., “1,1′-(Azodicarbonyl)dipiperidine-Tributylphosphine, A New Reagent System for Mitsunobu Reaction”, Tetrahedron Letters, vol. 34, No. 10, 1993, pp. 1639-1642.
Wolfe et al., “An Improved Catalyst System for Aromatic Carbon—Nitrogen Bond Formation: The Possible Involvement of Bis(Phosphine) Palladium Complexes as Key Intermediates”, J. Am. Chem. Soc., 1996, vol. 118, pp. 7215-7216.
Zeng et al., “Design of New Topoisomerase II Inhibitors Based upon a Quinobenzoxazine Self-Assembly Model”, J. Med. Chem., 199, vol. 41, pp. 4273-4278.
Alcaraz Lilian
Furber Mark
Mortimore Michael
Pimm Austen
Thorne Philip
AstraZeneca AB
Morgan & Lewis & Bockius, LLP
Nolan Jason M.
Saeed Kamal A.
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