Acylation of 7-aminocephalosporanic acids

Details Acylation of 7-aminocephalosporanic acids Acylation of 7-aminocephalosporanic acids

1973-12-26

1979-12-18

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2602391, 544 29, 544 30, C07D50104, C07D50106

Patent

active

041795571

ABSTRACT:
6-Aminoacylamidopenicillanic acid or 7-aminoacylamidocephalosporanic acids are produced in high yields by acylating 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an amino acid, or a functional equivalent thereof, having its amino group protected with N,N-disubstituted .beta.-keto acid amide, and then removing the protecting group from the resulting protected 6-aminoacylamidopenicillanic acid or protected 7-aminoacylamidocephalosporanic acid by hydrolysis.

REFERENCES:
patent: 3812110 (1974-05-01), Leeet al.
patent: 3842072 (1974-10-01), Heusler et al.

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