Acyl polymeric derivatives of aromatic hydroxyl-containing compo

Details Acyl polymeric derivatives of aromatic hydroxyl-containing compo Acyl polymeric derivatives of aromatic hydroxyl-containing compo

1997-10-10

2000-01-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 48, 560 19, 536 111, A61K 3133, C07D49122

Patent

active

060110422

ABSTRACT:
The present invention is directed to conjugates such as polymeric prodrugs of aromatic, hydroxyl-containing compounds and methods of making and using the same. These polymeric prodrugs are preferably esters of hydroxyl-containing aromatic compounds and are formed by reacting a desired aromatic, hydroxyl-containing compound with a substantially non-antigenic polymer so as to produce a transport form having an ester linkage between the aromatic compound and the polymer. Preferred aromatic hydroxyl-containing compositions include 10- and 11-hydroxycamptothecin derivatives. Methods of treatment are also disclosed.

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