Immunotargeting of plasminogen activators to the pulmonary endot

Details Immunotargeting of plasminogen activators to the pulmonary endot Immunotargeting of plasminogen activators to the pulmonary endot

1995-03-30

1997-08-05

Feisee, Lila

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

5303871, 530380, 530830, 530350, 53038826, 5303917, 4241561, 4241451, 4241811, 435215, 435216, 435217, 435195, A61K 3516, A61K 3542, A61K 3836, A61K 39395

Patent

active

056539797

ABSTRACT:
A multimolecular complex made up of a plasminogen activator conjugated to anti-ACE Mab 9B9 capable of delivering the plasminogen activator to the pulmonary endothelium is provided. Methods of using this complex to selectively deliver the plasminogen activator to the pulmonary endothelium to enhance fibrinolysis in the lungs of an animal are also provided. In addition, a method of prolonging the time a plasminogen activator is present in the circulation of an animal by conjugating the plasminogen activator to anti-ACE Mab 9B9 is also provided.

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