Active carbonates of polyalkylene oxides for modification of pol

Details Active carbonates of polyalkylene oxides for modification of pol Active carbonates of polyalkylene oxides for modification of pol

1990-04-19

1992-06-16

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

430363, 430389, 430406, 430410, 435177, 435188, 546208, 546243, 548435, 548465, 548475, 548542, C07D20746, C07D21194

Patent

active

051226146

ABSTRACT:
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

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patent: 4891430 (1990-01-01), Barcelo et al.
Matsuda et al., Chemical Abstracts, vol. 111 (1989) 112046m.
Abuchowski, et al., Cancer Biochem. Biophys. 1984; 7: 175-178 (Exhibit D).

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