Activation of mutated RAC-PK

Details Activation of mutated RAC-PK Activation of mutated RAC-PK

2011-03-01

2011-03-01

Hobbs, Lisa J (Department: 1657)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S069100, C435S320100, C435S252300, C536S023200, C424S094500

Reexamination Certificate

active

07897371

ABSTRACT:
The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor.

REFERENCES:
patent: 5422125 (1995-06-01), Skyler et al.
Konishi et al. (1995) Biochem. Biophys. Res. Comm., vol. 216(2): 526-534.
Alessi et al. (1996) EMBO J. 15(23): 6541-6551.

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