Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2004-11-10
2010-10-26
Ton, Thaian N (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S007320, C435S041000, C435S042000, C435S069100, C435S069700, C435S440000, C536S023100, C536S023200, C536S023400
Reexamination Certificate
active
07820442
ABSTRACT:
The present invention identifies that the expression of Activation Induced Deaminase (AID) or its homologues in cells confers a mutator phenotype and thus provides a method for generating diversity in a gene or gene product as well as cell lines capable of generating diversity in defined gene products. The invention also provides methods of modulating a mutator phenotype by modulating AID expression or activity.
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Beale Rupert Christopher Landsdowne
Harris Reuben
Neuberger Michael Samuel
Petersen-Mahrt Svend K.
Leydig , Voit & Mayer, Ltd.
Medical Research Council
Ton Thaian N
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