Acrylamidobenzoic acid derivatives and their use

Details Acrylamidobenzoic acid derivatives and their use Acrylamidobenzoic acid derivatives and their use

1989-08-07

1991-04-09

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514365, 514372, 514385, 514399, 514400, 514403, 514406, 514408, 514423, 514428, 514438, 514440, 514448, 549 39, 549 71, 549 77, 548146, 548201, 548204, 548214, 548341, 548342, 548378, 548561, 548565, 548568, A61K 3140, A61K 31425, A61K 31415, C07D33902, C07D33322, C07D20718, C07D23110, C07D23354

Patent

active

050065483

ABSTRACT:
Compounds of the general formula: ##STR1## wherein R.sup.1 is heterocyclic group other than pyridyl and which is unsubstituted or substituted with lower alkyl or lower alkoxycarbonyl, R.sup.2 is hydrogen, halogen, or nitro, and R.sup.3 is carboxy group or its functional derivative, with the proviso that when R.sup.1 is an unsubstituted furyl, or furyl mono- or polysubstituted with alkyl and R.sup.2 is hydrogen, then R.sup.3 is functional derivative of carboxy and, where applicable, pharmaceutically acceptable salts thereof are hyaluronidase inhibitors and useful as anti-allergic agent.

REFERENCES:
patent: 4381305 (1983-04-01), Casagrande et al.
Pharmazie, 30, HS, 76-77, 1975, by El-Kerdawy, et al.
J. Drug Res. Egypt, 7, (1), 105-110 (1975), by El-Kerdawy, et al.
Chemotherapy, 12, (5), 371-374 (1964), by Momoki, et al.
Chem. Abstract, vol. 60 2986h (1964).

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