Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors

Details Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors

1989-05-24

1991-04-09

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514422, 514469, 546269, 548525, 549320, 549471, 549 60, A61K 3138, A61K 3144, C07D40900, C07D30512

Patent

active

050065491

ABSTRACT:
Novel 7-Aroyl-4-Hydroxy-3-Methyl-Benzofurans of the following general formula (I) are disclosed: ##STR1##

REFERENCES:
patent: 4172082 (1979-10-01), Moore
patent: 4431656 (1984-02-01), Katsumi et al.
patent: 4548948 (1985-10-01), Ward et al.
patent: 4743606 (1988-05-01), Lazer
patent: 4775679 (1988-10-01), Chang et al.
patent: 4816473 (1989-03-01), Dunn
Annual Reports in Medicinal Chemistry, vol. 22, Chapter 20, p. 205, (1987).
Annual Reports in Medicinal Chemistry, vol. 23, Section 4, pp. 184-189 (1989).
Katsumi, Ikuo et al., Studies on Styrene Derivatives II Synthesis and Anti-inflammatory Activity of 3,5-Di-tert-butyl-4-hydroxystyrenes, Chem. Pharm. Bull., vol. 34, pp. 1619-1627 (1986).
Lazer, E.S. et al., Antiinflammatory 2,6-Di-tert-butyl-4-(2-arylethenyl) phenyls, J. Med. Chem., vol. 32, pp. 100-104 (1989).

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