Acid pyrazole derivatives, preparation method therefor, use ther

Details Acid pyrazole derivatives, preparation method therefor, use ther Acid pyrazole derivatives, preparation method therefor, use ther

1998-04-22

1999-08-24

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548251, 5483741, C07D40104, C07D25704, C07D23118

Patent

active

059426225

DESCRIPTION:

BRIEF SUMMARY
The present invention relates to new derivatives of acid pyrazoles, their preparation process, the new intermediates obtained, their use as medicaments, the pharmaceutical compositions containing them and the new use of such derivatives of acid pyrazoles.
The subject of the present invention is the products of formula (I): ##STR1## in which one of A and B represents a nitrogen atom and the other of A and B represents a methine radical, defined as follows: linear or branched alkyl or alkenyl radical containing at most 10 carbon atoms, unsaturated cyclic radical constituted by 3 to 7 members, and optionally containing one or more identical or different heteroatoms chosen from oxygen, sulphur and nitrogen atoms, linear or branched alkyl or alkenyl radical containing at most 10 carbon atoms, optionally substituted by a cycloalkyl radical containing 5 or 6 members itself optionally substituted by a carboxy, alkyl, alkoxy, alkoxyalkyl, carboxyalkyl or carboxyalkoxyalkyl radical, containing at most 6 carbon atoms, branched alkyl, alkenyl or alkylthio radical containing at most 10 carbon atoms, or a cycloalkylthio radical, containing 5 or 6 members, all of these radicals being optionally substituted by a carboxy or phenyl radical itself optionally substituted by a free or esterified carboxy radical, a linear or branched alkyl or alkoxy radical containing at most 4 carbon atoms, radical containing at most 4 carbon atoms, isosteric function, unsaturated, and diastereoisomeric isomer forms, as well as the addition salts with mineral and organic acids or with mineral and organic bases of said products of formula (I).
In the products of formula (I) and in what follows: radicals: methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, isohexyl and also heptyl, octyl, nonyl and decyl as well as their linear or branched position isomers, radicals: vinyl, allyl, 1-propenyl, butenyl, 1-butenyl, pentenyl or hexenyl as well as their linear or branched position isomers, members and optionally containing one or more identical or different heteroatoms, chosen from oxygen, sulphur or nitrogen atoms designates on the one hand a cycloalkyl radical which itself designates in particular the cyclopentyl and cyclohexyl radicals or a carbocyclic radical interrupted by one or more heteroatoms chosen from oxygen, nitrogen or sulphur atoms such as quite particularly the dioxolane, dioxane, dithiolane, thiooxolane or thiooxane radical, radicals radical, radicals: methoxy, ethoxy, propoxy, isopropoxy, linear, secondary or tertiary butoxy, pentoxy or hexoxy as well as their linear or branched position isomers, is as defined above such as for example in methylthio, ethylthio, propylthio, isopropylthio, butylthio, sec-butylthio, tert-butylthio, isopentylthio, isohexylthio, but also heptylthio, octylthio, nonylthio or decylthio as well as their linear or branched position isomers, cyclohexylthio radicals.
Among the alkoxyalkyl radicals the following radicals can be mentioned: methoxymethyl, ethoxymethyl, methoxyethyl, ethoxypropyl, propyloxymethyl, propyloxypropyl or also propyloxyethyl.
The alkyl and alkoxyalkyl radicals as defined above can be substituted by a free, salified or esterified carboxy radical to give the corresponding carboxyalkyl and carboxyalkoxyalkyl radicals, represent a fluorine, bromine or iodine atom, salified or esterified carboxy radical, the free or salified tetrazolyl radical, or the following radicals: containing at most 6 carbon atoms or a phenyl, pyridyl, pyrimidinyl, piperazinyl, thienyl or tetrazolyl radical, the alkyl, alkenyl and phenyl radicals being optionally substituted by one or more radicals chosen from halogen atoms and hydroxy, alkoxy or phenyl radicals, all the phenyl radicals and the piperazinyl radical being optionally substituted by a linear or branched alkyl radical containing at most 4 carbon atoms.
The carboxy radical or radicals of the products of formula (I) can be salified or esterified by various groups known to a man skilled in the art amongst which t

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