Acetylenic esters

Details Acetylenic esters Acetylenic esters

1989-08-01

1990-02-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514467, 514549, 514557, 514567, 549214, 549215, 549229, 556419, 556437, 556438, 560183, 562555, 562598, A61K 31695, C07F 718

Patent

active

048988537

ABSTRACT:
This invention relates to acetylenic esters that are useful in the treatment of fungal diseases and hypercholesterolemic conditions.

REFERENCES:
patent: 4024278 (1977-05-01), Henrick
patent: 4640909 (1987-02-01), Ramsden et al.
patent: 4806565 (1989-02-01), Hensens et al.
M. D. Lewis & R. Menes, "Absolute and Relative Configuration of L-660, 631," Tetrahedron Lett., 43, 5129-5132 (1987).
R. M. Hanson & K. B. Sharpless, "Procedure for the Catalytic Asymmetric Epoxidation of Allylic Alcohols in the Presence of Molecular Sieves," J. Org. Chem., 51, 1922-1925 (1986).
M. Mehrabian et al., "Regulation of Rat Liver 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthetase . . . ," J. Biol. Chem. 261, 16249-16255 (1986).
M. Patel et al., Novel Antifungal Antibiotics, Sch 31828, Produced by Miccrobispora sp. SCC 1438, Abst. 983 of the 1987 Interscience Conference on Antimicrobial Agents & Chemotherapy.

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