Acetoxymethyl penam compounds as .beta.-lactamase inhibitors

Details Acetoxymethyl penam compounds as .beta.-lactamase inhibitors Acetoxymethyl penam compounds as .beta.-lactamase inhibitors

1979-09-26

1981-03-17

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

2602452R, 424271, C07D49900, A61K 3143

Patent

active

042567335

ABSTRACT:
2.beta.-Acetoxymethyl-2.alpha.-methyl-(5R)penam-3.alpha.-carboxylic acid 1,1-dioxide, pharmaceutically-acceptable salts thereof and esters thereof readily hydrolyzable in vivo; pharmaceutical compositions containing 2.beta.-acetoxymethyl-2.alpha.-methyl-(5R)penam-3.alpha.-carboxylic acid 1,1-dioxide or salt or ester thereof; and method of enhancing the effectiveness of a .beta.-lactam antibiotic using 2.beta.-acetoxymethyl-2.alpha.-methyl-(5R)penam-3.alpha.-carboxylic acid 1,1-dioxide or salt or ester thereof.

REFERENCES:
Chakovskaya et al., Antibiotiki 13, 155 (1968).
Barton et al., JCS (London) Part D, 1683 (1970).
1bid Part C, 3540 (1971).
Morin et al., JACS 91, 1401 (1969).
Hauser et al., Helvetica Chimica Acta 50, 1327 (1967).
Vanderhaeghe et al., Recent Advances in the Chemistry of .beta.-Lactam Antibiotics, J. Elus Editor, The Chemical Society (London) Special Publication No. 28, Chap. 32, pp. 304-313.

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