Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-05-16
2006-05-16
Russel, Jeffrey Edwin (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S357000, C514S359000, C514S361000, C514S365000, C514S367000, C514S374000, C514S376000, C514S378000, C514S392000, C514S400000, C514S406000, C514S423000, C514S438000, C514S443000, C514S466000, C514S471000, C514S561000, C514S563000, C514S564000, C546S173000, C546S334000, C548S127000, C548S163000, C548S204000, C548S217000, C548S221000, C548S228000, C548S235000, C548S247000, C548S255000, C548S324500, C548S339100, C548S339500, C548S375100, C548S531000, C548S540000, C548S557000
Reexamination Certificate
active
07045532
ABSTRACT:
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I):in-line-formulae description="In-line Formulae" end="lead"?Z-Λ (I)in-line-formulae description="In-line Formulae" end="tail"?Wherein Z is a zinc coordinating moiety and Λ is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.
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Roberts et al.,Basic Principles of Organic Chemistry, 2nded. Menlo Park: W.A. Benjamin, Inc., pp. 1208-1210 (1977).
Acton Susan L.
Brown James A.
Dales Natalie A.
Gould Alexandra E.
Guan Bing
Fish & Richardson P.C.
Millennium Pharmaceuticals Inc.
Russel Jeffrey Edwin
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