Absorbent of autoantibody and immune complexes, adsorbing device

Details Absorbent of autoantibody and immune complexes, adsorbing device Absorbent of autoantibody and immune complexes, adsorbing device

1984-03-23

1986-12-09

Spear, Frank

Liquid purification or separation

Recirculation

Serially connected distinct treating or storage units

210434, 210927, B01D 1500

Patent

active

046279156

ABSTRACT:
An adsorbent for adsorbing thereonto an autoantibody and/or immune complexes from a body fluid. The adsorbent comprises a surface, a hydrophobic member and a negative charge-producing member. The negative charge-producing member is adapted to produce such an effective number of negative charges in a body fluid that the ratio of: ##EQU1## is greater than 1. The adsorbent is excellent in selectively and efficiently adsorbing an autoantibody and/or immune complexes while little adsorbing useful substances from the body fluid. The adsorbent may be used in an adsorbing device comprising a vessel having a fluid inlet and a fluid outlet with the adsorbent contained in the vessel. The adsorbing device may be used in a blood purifying apparatus for adsorbing and removing an autoantibody and/or immune complexes from blood plasma, which apparatus comprises a blood circulation passage provided with a plasma separating means and a blood-plasma mixing means, and a plasma recycle passage connected to the blood circulation passage and adapted to introduce plasma, separated by the plasma separating means and purified by a plasma purifying means comprised of the above-mentioned adsorbing device and disposed in the plasma recycle passage, into the mixing device.

REFERENCES:
patent: 4243532 (1981-01-01), Tsuda et al.
patent: 4375414 (1983-03-01), Strahilevitz
patent: 4384954 (1983-05-01), Nakashima et al.
patent: 4421684 (1983-12-01), Nakashima et al.
patent: 4490290 (1984-12-01), Gani et al.

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