AbiZ phage resistance gene

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023700, C435S252900, C435S320100, C426S034000, C426S043000

Reexamination Certificate

active

10651768

ABSTRACT:
A first aspect of the present invention is an isolated nucleic acid encoding a phage abortive defense protein, the isolated nucleic acid selected from the group consisting of: (a) isolated nucleic acid having the sequence or coding sequence given in SEQ ID NO: 1 (by “coding sequence” is meant nucleotides 373 to 1668 therein); (b) isolated nucleic acid encoding a phage abortive defense protein and which hybridizes to an nucleic acid having the sequence or coding sequence given in SEQ ID NO: 1, and/or having a sequence at least 60, 70, 80, 90, 92 or 95 percent identical to the sequence or coding sequence given in SEQ ID NO: 1; and (c) isolated nucleic acid encoding a phage abortive defense protein encoded by an isolated nucleic acid of (a) or (b) above, but differing in sequence therefrom due to the degeneracy of the genetic code (e.g., a nucleic acid encoding the protein given in SEQ ID NO: 2).

REFERENCES:
patent: 4931396 (1990-06-01), Klaenhammer et al.
patent: 5139950 (1992-08-01), Klaenhammer et al.
patent: 5538864 (1996-07-01), Hill et al.
patent: 5593885 (1997-01-01), Klaenhammer et al.
patent: 5618723 (1997-04-01), Klaenhammer et al.
patent: 5792625 (1998-08-01), Klaenhammer et al.
patent: 6242194 (2001-06-01), Kullen et al.
Altschul et al.; Basic Local Alignment Search Tool,J. Mol. Biol., 215:403-410 (1990).
Altschul et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,Nucleic Acids Research, vol. 25, No. 17:3389-3402 (1997).
Dinsmore, P.K., et al., “Characterization of a Genomic Region in aLactococcusBacteriophage That is Involved in Its Sensitivity to the Phage Defense Mechanism AbiA†,”Journal of Bacteriology, 1997, pp. 2949-2957, vol. 179(9).
Durmaz, E., et al., “Molecular Characterization of a Second Abortive Phage Resistance Gene Present inLactococcus lactissubsp.lactisME2†,”Journal of Bacteriology, 1992, pp. 7463-7469, vol. 174(22).
Higgins, D.L., et al., “Restriction and Modification Activities fromStreptococcus lastisME2 are Encoded by a Self-Transmissible Plasmid, pTN20, that Forms Cointegrates During Mobilization of Lactose-Fermenting Ability†,”Journal of Bacteriology, 1998, pp. 3435-3442, vol. 170(8).
Hill, C., et al, “Nucleotide Sequence and Distribution of the pTR2030 Resistance Determinant (hsp) Which Aborts Bacteriophage Infection inLactococci†,” Applied and Environmental Microbiology, 1990, pp. 2255-2258, vol. 56(7).
Hill, C., et al., “The Conjugative Plasmid pTR2030 Encodes Two Bacteriophage Defense Mechanisms inLactococci, Restriction Modification (R+/M+) and Abortive Infection (Hsp)+†,”Applied and Environmental Microbiology, 1989, pp. 2416-2419, vol. 55(9).
Hill, C., et al., “Localization, Cloning, and Expression of Genetic Determinants for Bacteriophage Resistance (Hsp) from the Conjugative Plasmid pTR2030†,”Applied and Environmental Microbiology, 1989, pp. 1684-1689, vol. 55(7).
Klaenhammer, T.R., et al., “Molecular Analysis of pTR2030 Gene systems That Confer Bacteriophage Resistance toLactococci†,” Applied and Environmental Microbiology, 1991, pp. 124-130.
O'Sullivan, D.J., et al., “In vivo Restriction byLlaI is Encoded by Three Genes, Arranged in an Operon withIIaIM, on the ConjugativeLactococcusPlasmid pTR2030†,”Journal of Bacteriology, 1995, pp. 134-143, vol. 177(1).
Romero, D.A., et al., “Abortive Phage Infection and Restriction/Modification Activities Directed by pTR2030 Determinants are Enhanced by Recombination with Conjugal Elements inLactococci,” Journal of General Microbiology, 1990, pp. 1817-1824, vol. 136.
Romero, D.A., et al., “Characterization of Insertion Sequence IS946, an Iso-ISS1 Element, Isolated from the ConjugativeLactococcalPlasmid pTR2030†,”Journal of Bacteriology, 1990, pp. 4151-4160, vol. 172(8).

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