A54145 antibiotics and process for their production

Details A54145 antibiotics and process for their production A54145 antibiotics and process for their production

1988-04-11

1991-02-19

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514 9, 514 11, 530317, 530323, 426635, 435 713, 435 896, 435169, A61K 3574, C07K 754

Patent

active

049942700

ABSTRACT:
New peptide antibiotic A54145, individual A54145 components A, A.sub.1, B, B.sub.1, C, D, E and F and their pharmaceutically acceptable salts, are useful antibacterial agents which also improve growth performance in animals, especially poultry. Biologically pure cultures of the A54145-producing Streptomyces fradiae cultures NRRL 18158, NRRL 18159 and NRRL 18160 cultures and methods of making antibiotic A54145 using those cultures are also provided.

REFERENCES:
patent: Re31396 (1983-09-01), Hamill et al.
patent: Re32333 (1987-01-01), Hamill et al.
patent: Re32455 (1987-07-01), Hamill et al.
patent: 4024245 (1977-05-01), Hoehm et al.
patent: 4208403 (1980-06-01), Hamill et al.
patent: 4331594 (1982-05-01), Hamill et al.
patent: 4638047 (1987-01-01), Szelke et al.
J. Normansell, The Bacteria, vol. IX, Chapter 4, "Isolation of Streptomyces Mutants Improved for Antibiotic Production", pp. 95-119, 1986.
A. Fantini, Methods in Enzymology, vol. XLIII, "Methods for the Study of Antibiotics, Strain Development," pp. 24-41, 1975.
S. Queener and D. Lively, The Manual of Industrial Microbiology and Biotechnology, Chapter 12, "Screening and Selection for Strain Improvement," pp. 155-169, 1986.

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