A3 adenosine receptor, DNA, and uses

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Algae – media therefor

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435 6, 435 691, 4353201, 536 235, 536 2431, C12N 1512

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054418836

ABSTRACT:
The present invention relates to a novel mammalian adenosine receptor. The invention is directed toward the isolation, characterization and pharmacological use of the rat A3 adenosine receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing the rat A3 adenosine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize the rat A3 adenosine receptor. The invention also provides methods for screening adenosine-receptor agonists and antagonists in vitro using preparations of the rat A3 adenosine receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the rat A3 adenosine receptor gene.

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