Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-01-16
1991-11-19
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514431, 540468, 540476, A61K 3133, A61K 3138, C07D26722, C07D48700
Patent
active
050666495
ABSTRACT:
The invention relates to a new group of 8,9-annelated-1,2,3,4-tetrahydro-.beta.-carbolines of the formula ##STR1## and the salts and prodrugs thereof. The meanings of R.sub.1, n, Z, R.sub.2, R.sub.3, and R.sub.4 are defined within the body of the specification.
It has been found that the compounds have good fibrinolytic properties and can be used in particular as orally active fibrinolytics.
REFERENCES:
patent: 3914421 (1975-10-01), Rajagopalan
patent: 4782061 (1988-01-01), Kruse et al.
Lysis of Clots Prepared from Whole Blood and Plasma, Fletcher B. Taylor et al., Federation Proceedings 40 pp. 2092-2098 (1981).
Culture of Arterial Endothelial Cells, F. M. Booyse et al., Thrombos. Diathes. Haemorrh. (Stuttg.), pp. 825-839 (1975).
Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma, J. H. Verheijen et al., Thromb Haemostas (Stuttgart) 51 (3) pp. 392-395 (1984).
A. Tetrahydrocarbolines, Advances in Heterocyclic Chemistry 3, pp. 83-91 (1964).
Some 5,6-Dihydro-4H-Pyrrolo[3,2,1-i,j]Quinolines, Heterocyclic Chemistry II, pp. 387-393 (1974).
The Preparation of 3,4-Dihydroisoquinolines and Related Compouds, Wilson et al., Organic Reaction 6, pp. 74-80 (1951).
Chemical Abstracts 112 20979k.
Chemical Abstracts 84 59411x.
Chemical Abstracts 111 77986u.
Hamminga Derk
Jansen Johannes W. C. M.
Van Wijngaarden Ineke
Duphar International Research B.V.
Grumbling Matthew V.
Shah Mukund J.
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