8,12-Dialkyl-PGE, and PGF.sub.1.sub..alpha.

Details 8,12-Dialkyl-PGE, and PGF.sub.1.sub..alpha. 8,12-Dialkyl-PGE, and PGF.sub.1.sub..alpha.

1974-06-14

1976-04-27

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260468D, C07C 6136, C07C 6979

Patent

active

039534995

ABSTRACT:
Prostaglandins E.sub.1 -type and F.sub.1 -type compounds of the formula ##EQU1## wherein R is hydrogen or a hydrocarbyl group containing from 1 to 12 carbon atoms, inclusive, wherein W is ##EQU2## or O =, wherein R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 are hydrogen or alkyl of 1 to 4 carbon atoms, inclusive, provided (1) that at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl (2) that when R.sub.13 is alkyl, at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, and R.sub.14 is alkyl, and (3) that when R.sub.7 is alkyl or thwn R.sub.7 and R.sub.8 are alkyl, at least one of R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl; and the enantiomers and racemic mixtures thereof. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.

REFERENCES:
patent: 3514383 (1970-05-01), Beal et al.

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