7-(substituted or unsubstituted amino) 3-substituted methyl-.sup

Details 7-(substituted or unsubstituted amino) 3-substituted methyl-.sup 7-(substituted or unsubstituted amino) 3-substituted methyl-.sup

1987-03-06

1989-11-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D 31545

Patent

active

048793817

ABSTRACT:
Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.

REFERENCES:
patent: 3821206 (1974-06-01), Cowley
patent: 4143166 (1979-03-01), Takage
patent: 4148997 (1979-04-01), Haviv
patent: 4165430 (1979-08-01), Bradshaw
patent: 4343937 (1982-08-01), Christensen
patent: 4489072 (1984-12-01), Sadaki
patent: 4673738 (1987-06-01), Sadaki

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