7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acids and

Details 7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acids and 7-substituted derivatives of 3,5-dihydroxyhept-6-ynoic acids and

1989-09-22

1992-02-25

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 546268, 546341, C07D21355, C07D40506, A61K 3144

Patent

active

050913867

ABSTRACT:
7-Substituted 3,5-dihydroxyhept-6-ynoic acids and the derivatives thereof of the formula I ##STR1## as well as the corresponding lactones of the formula II ##STR2## in which R and R.degree. have the specified meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

REFERENCES:
patent: 4647576 (1987-03-01), Hoefle
patent: 4761419 (1922-08-01), Picard
patent: 4851427 (1989-07-01), Wareing
Stokker et al., "Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors 3. 5-Disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic Acids and Their Lactone Derivatives", 29 J. Med. Chem., No. 2, 170-181 (1986).
"Eptastatin Sdoium", 12 Drugs of the Future, No. 5, 437-442 (1987).
Baader et al., "Synthesis of a Novel HMG-CoA Reductase Inhibitor", 29 Tetrahedron Letters, No. 8, 929-930 (1988).
Stokker et al., "Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 1. Structural Modification of 5-Substituted 3,5-Dihydroxypentanoic Acids and Their Lactone Derivatives", 28 J. Med. Chem., No. 3, 347-358 (1985).

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