7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines

Details 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines

1978-06-28

1980-06-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424251, C07D48704, A61K 31505

Patent

active

042085209

ABSTRACT:
7-(Substituted)-pyrrolo[3,2-f]-quinazoline-1,3-diamines possess antibacterial activity in vitro. The invention also provides compounds having synergism in vivo with sulfa drugs against bacterial infections.

REFERENCES:
patent: 2945859 (1960-07-01), Hitchings et al.
patent: 3505330 (1970-04-01), Davoll et al.
patent: 4118561 (1978-10-01), Ledig
De Graw et al., J. Med. Chem., vol. 17, pp. 762-764 (1974).
Davoll et al., J. Med. Chem., vol. 15, pp. 812-826 (1972).
Elslager et al., J. Med. Chem., vol. 15, pp. 1138-1146 (1972).
Elslager, Progress in Drug Research, vol. 18, pp. 99-172 (1974).
Reed et al., Amer. J. Hyg., vol. 27, pp. 493-497 (1938).

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