7-oxabicycloheptane substituted amide prostaglandin analogs

Details 7-oxabicycloheptane substituted amide prostaglandin analogs 7-oxabicycloheptane substituted amide prostaglandin analogs

1986-02-24

1987-03-24

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514469, 548252, 549463, C07D49308, C07D40514, A61K 3134, A61K 3141

Patent

active

046525785

ABSTRACT:
Cis-exo 7-oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR2## wherein R.sup.2 and R.sup.3 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.2 and R.sup.3 being other than hydroxy and lower alkoxy; X is O, NH, CH.dbd.CH, or --(CH.sub.2).sub.x wherein x is 0 or 1; and R.sup.1 is lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, amino, alkylamino, arylamino, arylthio or alkylthio.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

REFERENCES:
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4418076 (1983-11-01), Nakane et al.
patent: 4456617 (1984-06-01), Nakane et al.
patent: 4526901 (1985-07-01), Nakane

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