6-thioxanthines

Details 6-thioxanthines 6-thioxanthines

1989-10-02

1991-04-23

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544273, C07D47338, A61K 3152

Patent

active

050100815

ABSTRACT:
A 6-thioxanthine of formula I or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.3 is a C.sub.2 to C.sub.6 alkyl group, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group and R.sub.8 is a C.sub.1 to C.sub.6 alkyl group, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group provided that when R.sub.3 is an ethyl, n-propyl or n-butyl group, R.sub.8 is a C.sub.3 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group.
These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity.

REFERENCES:
patent: 4710503 (1987-12-01), Hofer
patent: 4820709 (1989-04-01), Hofer
patent: 4925847 (1990-05-01), Hofer
Armitage et al, Brit. J. Pharmacol. vol. 17 pp. 196-207.

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