6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydr

Details 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydr 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydr

1987-12-07

1988-08-02

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514314, 546167, 546171, 546173, 546174, 546175, 544333, A61K 3134, A61K 3147, C07D21712, C07D21714

Patent

active

047614196

ABSTRACT:
Certain trans-6-[[(substituted)quinolinyl]ethyl]-and ethenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding dihydroxy ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

REFERENCES:
patent: 4198425 (1980-04-01), Mistui et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4262013 (1981-04-01), Mistui et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4613610 (1986-09-01), Wareing
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4668794 (1987-05-01), Wareing
patent: 4681893 (1987-07-01), Roth
PCT International Application No. PCT/EP83/00308 Pub. No. WO 84/02131.

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