6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-e thyl]-4(R)

Details 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-e thyl]-4(R) 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-e thyl]-4(R)

1980-08-05

1981-10-06

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562501, 424279, 424317, C07D30930, C07C 5911

Patent

active

042934966

ABSTRACT:
The title compounds are prepared by saponifying the corresponding 8-acyloxy compounds, with strong base at elevated temperatures to remove the hindered acyl group without disrupting the rest of the molecule. The products are useful as intermediates in the synthesis of antihypercholesterolemia agents.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4049495 (1977-09-01), Endo et al.
patent: 4137322 (1979-01-01), Endo et al.
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4255444 (1981-03-01), Willard
Singer et al., Proc. Soc. Exper. Biol. Med., 102, 370 (1959).
Hulcher, Arch. Biochem, Biophys. 146, 422 )1971).
Brown et al., J. Chem. Soc., Perkin I, 1165 (1976). _
Endo et al., J. Antibiotics XXXII, 852 (1979).
Derwent 15706c/09.

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