6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and composition

Details 6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and composition 6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and composition

1993-11-30

1996-07-30

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142342, 5142345, 544118, 544262, A61K 31505, A61K 31535, C07D41300, C07D21344

Patent

active

055411878

ABSTRACT:
Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclyl-carboxaldehyde or by reacting a 5-amino-1H-pyrazole-4-carbonitrile with a heterocyclylcarboxamidine, followed by diazotization and hydrolysis of the resulting 4-amino-6-heterocyclyl-pyrazolo[3,4-d]pyrimidine.

REFERENCES:
patent: 3165520 (1965-01-01), Schmidt et al.
patent: 3211731 (1965-10-01), Schmidt et al.
patent: 3350397 (1967-10-01), Burch
patent: 3732225 (1973-05-01), Breuer et al.
patent: 4167568 (1979-04-01), Knowles
patent: 4666908 (1987-05-01), Hamilton
patent: 5075310 (1991-12-01), Coates
Hamilton et al, Journal Med. Chem. vol. 30, pp. 91-96 (1987).
Burch,--J. Med. Chem. 1968, pp. 79-83.
Miyashita et al, Heterocycles, 1990, p. 1309.

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