6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions

Details 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions

1992-03-30

1994-03-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514249, 514258, 544118, 544124, 544262, 546121, 546164, 546168, 546169, 546279, 546286, 546330, 5483657, 5483677, 5483691, 549449, A61K 31505

Patent

active

052946126

ABSTRACT:
Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by reacting a 5-amino-1H-pyrazole-4-carbonitrile with a heterocyclylcarboxamidine, followed by diazotization and hydrolysis of the resulting 4-amino-6-heterocyclyl-pyrazolo[3,4-d]pyrimidine.

REFERENCES:
patent: 3165520 (1965-01-01), Schmidt et al.
patent: 3211731 (1965-10-01), Schmidt et al.
patent: 3211732 (1965-10-01), Schmidt et al.
patent: 3350397 (1967-10-01), Burch
patent: 3732225 (1973-05-01), Breuer et al.
patent: 4167568 (1979-04-01), Knowles
patent: 4666908 (1987-05-01), Hamilton
patent: 5075310 (1991-12-01), Coates
Tokkyo Koho Chem. Abstr. vol. 106 Entry 101967h abstracting Japan 61-236778 (1986).
Hamilton et al., Jour. Med. Chem. vol. 30 pp. 91-96 (1987).
Burch-J. Med. Chem. 1968, 11,-79.
Miyashita et al.-(Heterocycles 1990, 31, 1309).

Affiliated with

Also associated with

Rating

6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1536186