6-fluoroprostaglandins

Details 6-fluoroprostaglandins 6-fluoroprostaglandins

1988-10-14

1990-03-06

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560121, 562503, C07C17700, A61K 31557

Patent

active

049066633

ABSTRACT:
A 6-fluoroprostaglandin having the formula: ##STR1## wherein A is a carbonyl group or a hydroxymethylene group, R.sup.1 is a substituted or unsubstituted C.sub.1 -C.sub.10 alkyl group or a substituted or unsubstituted 5- or 6-membered cycloalkyl group, R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group, each of R.sup.3 and R.sup.4 which may be the same or different is a hydrogen atom or a protecting group, R.sup.5 is a hydrogen atom or a hydroxyl group, and is a single bond or a double bond, and its salt when R.sup.2 is a hydrogen atom.

REFERENCES:
patent: 4699989 (1987-10-01), Arata
Nakai, Chem. Lett., 1979, 1499.
Chemistry Letters, 1979, pp. 1499-1502, The Chemical Society of Japan, Nakai et al.: Synthesis of 5-fluoro-prostaglandins.

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