Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-01-14
1987-03-31
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544239, 560 19, 560 35, 562439, 562440, 562433, C07D23704, A61K 3150
Patent
active
046543422
ABSTRACT:
This invention relates to cyanoguanidine derivatives that have utility in the treatment of congestive heart failure. A specific compound of this invention is 6-[4-(N.sup.3 -methyl-N.sup.2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
REFERENCES:
patent: 3822260 (1974-07-01), Curran et al.
C. W. Thornber, Quarterly Reviews, p. 563 (1978).
Durant et al., J. Med. Chem. 20:901-906 (1977).
Durant et al., Burgers Medicinal Chemistry (John Wiley 1981), fourth edition, Chapter 48, p. 520.
Beattie et al., J. Med. Chem. 20, p. 719 (1977).
Tilley et al., J. Med. Chem. 23, p. 1438 (1980).
Petersen et al., J. Med. Chem. 21, p. 773 (1978).
Berch Mark L.
Daniel Mark R.
Lourie Alan D.
Smith Kline & French Laboratories Ltd.
Williams Janice E.
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