6-.beta.-substituted penicillanic acid compound free of the 6-.a

Details 6-.beta.-substituted penicillanic acid compound free of the 6-.a 6-.beta.-substituted penicillanic acid compound free of the 6-.a

1984-05-04

1987-04-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49900, A61K 31425

Patent

active

046562630

ABSTRACT:
6-.beta.-Substituted penicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria, and 6-.beta.-substituted penicillanic acid derivatives wherein the carboxy group is protected by a conventional penicillin carboxy protecting group as useful intermediates leading to said synergistic agents. A process for converting 6,6-disubstituted penicillanic acid derivatives to the corresponding 6-.beta.-substituted penicillanic acid congeners.

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patent: 4420426 (1983-12-01), Moore
patent: 4511512 (1985-04-01), von Dashne
patent: 4518330 (1985-05-01), Kellogg
patent: 4518530 (1985-05-01), Kellogg
Loosemore and Pratt, Journal of Organic Chemistry, 43, 3611 (1978).
Pratt and Loosemore, Proceedings of the National Academy of Sciences, U.S.A., vol. 75, pp. 4145-4149 (1978).
Roets, Vlietinck and Vanderhaeghe, Journal of the Chemical Society, (London), Perkin I, 704 (1976).
Knott-Hunziker, Orlek, Sammes and Waley, Biochemical Journal, 177, 365 (1979).

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