6- and 7-deoxyforskolin and derivatives thereof

Details 6- and 7-deoxyforskolin and derivatives thereof 6- and 7-deoxyforskolin and derivatives thereof

1989-07-06

1992-03-03

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 514211, 514212, 514218, 5142282, 5142285, 5142325, 5142328, 514253, 514316, 514320, 514321, 514333, 514338, 514369, 514376, 514397, 514385, 514422, 514432, 514452, 514453, 514455, 540480, 540481, 540524, 540544, 540575, 540597, 540601, 540602, 540603, 544265, 544317, 544316, 544318, 544 586, 544 587, 544 69, 544 79, 544114, 544121, 544122, 544123, 544130, 544131, 544133, 544137, 544145, 544148, 544150, 544295, 544296, 544229, 544357, 544364, 544238, 544375, 544372, 544369, 544360, 544367, 546187, 54

Patent

active

050933361

ABSTRACT:
Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are disclosed.

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patent: 4677103 (1987-06-01), Kosley, Jr. et al.
Barton et al., J. Chem. Soc., Perkin I, pp. 1574-1585 (1975).
Barton et al., J. Chem. Soc., Perkin I, pp. 1710-1723 (1977).
J. Caprioli et al., "Forskolin Lowers Intraocular Pressure by Reducing Aqueous Inflow", Invest. Ophtalmol. & Vis. Sci., 25, 268-277 (1984).
N. de Souza et al., "Forskolin: A Labdane Diterpenoid with Antihypertensive, Positive Inotropic, Platelet Aggregation Inhibitory, and Adenylate Cyclase Activating Properties", Med. Res. Rev., 3(2), 201-219 (1983).
S. Bhat et al., "The Antihypertensive and Positive Inotropic Diterpene Forskolin: Effects of Structural Modifications on its Activity", J. Med. Chem., 26 486-492 (1983).
K. Seamon et al., "Structure-Activity Relationships for Activation of Adenylate Cyclase by the Diterpene Forskolin and Its Derivatives", J. Med. Chem., 26(3), 436-439 (1983).
S. Bhat et al., "Reactions of Forskolin, a Biologically Active Diterpenoid From Coleus Forskohlii", J. Chem. Soc., Perkin I, 767-771 (1982).
K. Seamon and J. Daly, "Activation of Adenylate Cyclase by the Diterpene Forskolin Does Not Require the Guanine Nucleotide Regulatory Protein", J. Bio. Chem., 256(19), 9799-9801 (1981).
J. Takeda et al., "Forskolin Activates Adenylate Cyclase Activity and Inhibits Mitosis in In Vitro in Pig Epidermis", J. Investig. Derm., 81(3), 236-240 (1981).
K. Seamon et al., "Forskolin: Unique Diterpene Activator of Adenylate Cyclase in Membranes and in Intact Cells", Proc. Natl. Acad. Sci., 78(6), 3363-3367 (1981).
S. Bhat et al., "Structures and Stereochemistry of New Labane Diterpenoids from Coleus forskohlii Brig.", Tet. Lett., No. 19, 1669-1672 (1977).
Derwent Citation 85-223308/36, 231 "Treatment of Hyperplastic Skin Diseases, Especially Psoriasis, by Topical Application of Labdane Derivatives, Especially Forskolin", Aug. 1985.

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