6.alpha.-Bromopenicillanic acid sulfone

Details 6.alpha.-Bromopenicillanic acid sulfone 6.alpha.-Bromopenicillanic acid sulfone

1978-12-11

1980-05-20

Morgenstern, Norman

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

2602391, 2602452R, A61K 3143, C07D49944

Patent

active

042039932

ABSTRACT:
(2S,5R,6S)-6.alpha.-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept ane-2-carboxylic acid, S,S-dioxide, physiologically acceptable salts thereof and readily hydrolyzable ester thereof inhibit the action of the .beta.-lactamase enzyme RTEM.

REFERENCES:
patent: 3197466 (1965-07-01), Chow et al.
patent: 3741959 (1973-06-01), Looker et al.
Fisher et al., Annual Reports in Medicinal Chem. 13,239 (1978).
Cole, Enzyme Biotechnology, p. 222 (1978).
Clayton, J. Chem. Soc. (C), 2123, (1969).
Loosemore et al., J. Org. Chem. 43, (18) 3611 (1978).
Pratt et al., Proc. Natl. Acad. Sci. USA, 75 (9) 4145, (1978).
English et al., Antimicrobial Agents & Chemotherapy, 14(3) 414 (1978).
Sykes et al., J. of Antimic Chemotherapy, 2,115 (1976).

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