Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-06-16
1995-11-28
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 2713, 536 2714, 536 2721, 536 2761, 536 2763, 536 277, 544254, 544256, 544264, 544278, 548260, 5483044, A61K 3170
Patent
active
054708370
ABSTRACT:
The present invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering to said patient an effective immunosuppressive amount of certain 5'-vinylhalo-aristeromycin/adenosine analogs.
REFERENCES:
patent: 3472837 (1969-10-01), Verheyden et al.
patent: 4997924 (1991-03-01), Jarvi et al.
patent: 4997925 (1991-03-01), Jarvi et al.
Jenkins et al., "4'-Substituted Nucleosides. 2. Synthesis of the Nucleoside Antibiotic Nucleocidin," J. Am. Chem. Soc., 98(11), 3347-3357 (1976).
R. S. Root-Bernstein(I), "AIDS Is More Than HIV: Part I," Genetic Engineering News, Sep. 1, 1992, pp. 4-6.
R. S. Root-Bernstein(II), "AIDS Is More Than HIV: Part II," Genetic Engineering News, Sep. 15, 1992, pp. 4-5.
Wolos et al.(I), "Immunomodulation by an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase: Inhibition of in Vitro and in Vivo Allogeneic Responses," Cellular Immunology, 149, 402-408 (1993).
Wolos et al.(II), "Immunosuppression Mediated by an Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase," J. Immunology, 151(1), 526-534 (1993).
Wolos et al.(III), "Selective Inhibition of T-Cell Activation by and Inhibitor of S-Adenosyl-L-Homocysteine Hydrolase," J. Immunology, 150(8), 3264-3273 (1993).
Wolos et al.(IV), "Suppression of in Vitro and in Vivo T Cell Function by an Inhibitor of S-Adenosyl Homocysteine Hydrolase," Abstract No. 0-427, Keystone Symposia on Molecular & Cellular Biology, 20th Annual Meeting, published in J. Cellular Biochem., Supplement 15E, 1991, Wiley-Liss (publisher), see p. 187.
Schmidt et al., "3-Deazaadenosine-An Inhibitor of Interleukin 1 Production by Human Peripheral Blood Monocytes," Int. J. Immunopharmac., 12(1), 89-97 (1990).
Puck et al., "Regulatory Interactions Governing the Proliferation of T Cell Subsets Stimulated by Pokeweed Mitogen," J. Immunology, 132(3), 1106-1112 (1984).
Hom et al., "The Progression of the Inflammation in Established Collagen-Induced Arthritis Can be Altered by Treatments with Immunological of Pharmacological Agents which Inhibit T Cell Activities," Eur. J. Immunology, 18, 881-888 (1988).
Burmester et al., "T-Cell Regulation and T Cell Clones in Relation to Synovial Inflammation," published in Springer Seminars in Immunopathology, vol. 11, Springer-Verlag publ., 1989, pp. 259-272.
Sinha et al., "Autoimmune Diseases: The Failure of Self Tolerance," Science, 248, 1380-1388 (1990).
Henderson et al., "Mediators of Rheumatoid Arthritis," British Med. Bull., 43(2), 415-428 (1987).
Kyle et al., "Beneficial Effect of Monoclonal Antibody to Interleukin 2 Receptor on Activated T Cells in Rheumatoid Arthritis," Annals Rheumatic Diseases, 48, 428-429 (1989).
McCarthy et al.,(I), "The Synthesis of Unsaturated Adenine Nucleosides Related of Angustmycin A," Chem. Comm., 1967, 536-537.
Palmer et al., "The Mechanism of Action of S-Adenosylhomocysteinase," J. Biol. Chem., 254(4), 1217-1226 (1979).
Chiang et al., "S-Adenosyl-L-homocysteine Hydrolase: Analogues of S-Adenosyl-L-Homocysteine as Potential Inhibitors," Molecular Pharmacology, 13, 939-947 (1977).
Vinegar et al.(I), "Quantitative in vivo Studies of the Acute Actions of Anti-inflammatory Drugs in the Rat," Eur. J. Rheumatol. Inflamm., 1, 204-211 (1978).
Vinegar et al. (II), "Some Quantitave Temporal Characteristics of Carrageenin-Induced Pleurisy in the Rat (37397)," Proc. Soc. Exp. Biol. Med., 143, 711-714 (1973).
Medhi et al., "The Mechanism of Inhibition of S-Adenosyl-L-Homocysteine Hydrolase by Fluorine-Containing Adenosine Analogs," J. Enzyme Inhibitors, 4, 1-13 (1990).
Jarvi et al. (IV), "4',5'-Unsaturated 5'-Halogenated Nucleosides. Mechanism-Based and Competitive inhibitors of S-Adenosyl-L-homocysteine Hydorlase," J. Med. Chem., 34, 647-656 (1991).
McCarthy et al.(II), "4',5'-Unsaturated 5'-Fluoroadenosines Nucleosides: Potent Mechanism Based Inhibitors of S-Adenolyl-L-homocysteine Hydrolase," J. Am. Chem. Soc., 111, 1127-1128 (1989).
Doherty Niall S.
Jarvi Esa T.
McCarthy James R.
Wolos Jeffrey A.
Crane L. Eric
Merrell Dow Pharmaceuticals Inc.
Payne T. Helen
Robinson Douglas W.
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