5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo analogs of .beta.

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540214, C07D51304

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active

054460387

ABSTRACT:
5-Thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo analogs of .beta.-lactam, processes for the preparation thereof and the use thereof
Disclosed are novel 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo .beta.-lactam analogs of the general formula I ##STR1## wherein R.sup.1 is hydrogen or halo;

REFERENCES:
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Ross, et al., Penem derivatives, Eur. Pat. Appl. EP 31,509, 28-Heterocycles, vol. 96, 1982, p. 669.
Sempuku, Cephalosporin-related compounds, Dainippon Pharmaceutical Co., Ltd., Jpn. Kokai Tokkyo Koho JP 59 01,491, Chemical Abstracts, vol. 101 (1984) p. 624.
Gregory, Recent Advances in the Chemistry of .beta.-Lactam Antibiotics, Special Publication No. 38, Cambridge, England, 30th Jun.-2nd Jul., 1980.
Campbell, et al., New Reaction of Penicillins: the Formation, and Crystal and Molecular Structure of a .beta.-Lactam-fused Heterocyclic Ylide, J. C. S. Chem. Comm., 1974, p. 868.
Campbell, et al., Transformations of Penecillins: Reactions with Chloramine T, J. C. S. Perkin I, p. 1208.
Doyle, et al., Nuclear analogs of .beta.-lactam antibiotics. VI. Synthesis of N-2-isocephems. Can. J. Chem. vol. 55 (1977).

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