5-pyrimidinecarboxyamides and treatment of leukemia therewith

Details 5-pyrimidinecarboxyamides and treatment of leukemia therewith 5-pyrimidinecarboxyamides and treatment of leukemia therewith

1985-04-22

1987-01-13

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 49, 514 50, 514269, 514908, 536 23, 544301, 544319, A61K 31515, A61K 31505, C07D23952, C07D23960

Patent

active

046365087

ABSTRACT:
Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: ##STR1## wherein R.sub.1 is hydrogen or an alkoxy group having from one to four carbon atoms;

REFERENCES:
patent: 3961061 (1976-06-01), Kramer et al.
patent: 4229454 (1980-10-01), Beriger
patent: 4349552 (1982-09-01), Takaya et al.
patent: 4399280 (1983-08-01), de Sousa et al.
Brewer et al., Biochemical Pharmacology, vol. 34, No. 11, pp. 2047-2050, 1985.

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