[(5-oxo)-2-pyrrolidinyl)methyl]cyclohexaneacetamides, compositio

Details [(5-oxo)-2-pyrrolidinyl)methyl]cyclohexaneacetamides, compositio [(5-oxo)-2-pyrrolidinyl)methyl]cyclohexaneacetamides, compositio

1990-06-07

1991-05-14

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514424, 548336, 548543, A61K 3140, A61K 31415, C07D20712, C07D40308

Patent

active

050156535

ABSTRACT:
[(5-oxo-2-pyrrolidinyl)methyl]cyclohexaneacetamides of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or aryl-lower alkyl; R.sub.2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, ##STR2## wherein R.sub.5 and R.sub.6 are hydrogen, lower alkyl or aryl-lower alkyl; R.sub.3 and R.sub.4, independently, are hydrogen, lower alkyl, or aryl-lower alkyl; and enantiomers, diastereomers, and racemates thereof, and, when R.sub.2 is ##STR3## pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I exhibit cognitive enhancement and antiamnestic activity and are therefore useful, for example, in treating memory deficits associated with Alzheimer's disease or age-associated memory impairment.

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