Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-10-12
1997-11-04
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544105, A61K 31535, C07D41312, C07D49808
Patent
active
056840039
ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.
REFERENCES:
patent: 5187166 (1993-02-01), Kikuchi et al.
patent: 5256656 (1993-10-01), Kikuchi et al.
Trends in Pharmacological Science, vol. 13, "The 5-HT.sub.4 Receptor: A Place in the Sun", Bockaert, et al. Apr. 1992, pp. 141-145.
J. Am. Chem. Soc., vol. 104, 6876-6877, (1982), Grochowski et al.
Naunyn-Schmiedeberg's Arch Pharmacol, "SDZ 205-557, A Selective, Surmountable Antagonist for 5-HT.sub.4 Receptors in the Isolated Guinea Pig Ileum", Buchheit, et al. (1992) pp. 387-393.
Nauyn-Schmiedeberg's Arch Pharmacol, "5-Hydroxytryptamine.sub.4, Receptors Mediate Relaxation of the Rat Oesophageal Tunica Muscularis Mucosae", Baxter, et al. (1991) pp. 439-446.
Arai Takeo
Fukutomi Ruta
Hagihara Koichiro
Kikuchi Haruhiko
Mino Setsuko
Datlow Philip I.
Nisshin Flour Milling Co. Ltd.
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