5-fluoro-2'-deoxyuridine derivatives and a process for the prepa

Details 5-fluoro-2'-deoxyuridine derivatives and a process for the prepa 5-fluoro-2'-deoxyuridine derivatives and a process for the prepa

1982-12-09

1986-08-12

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 29, C07H 1512, C07H 1700

Patent

active

046056459

ABSTRACT:
5-fluoro-2'-deoxyuridine derivatives expressed by general formula (1) and their pharmacologically permissible salts ##STR1## wherein A indicates a saturated or unsaturated divalent aliphatic hydrocarbon group having 1 to 30 carbon atoms; the letter n indicates 0 or 1, and when n is 0, it indicates that Y is directly bound to an oxygen atom; Y represents a hydrogen atom, phenyl group, or substituted phenyl group; however, when Y is a hydrogen atom, n is 1; R indicates a hydrogen atom or alcohol-protecting group.
These compounds have a very strong antitumor activity.

REFERENCES:
patent: 4247544 (1981-01-01), Bergstrom et al.
patent: 4468384 (1984-08-01), Bardos et al.
patent: 4472386 (1984-09-01), Kodama et al.
DeClercq, Meth and Find Exptl Clin. Pharmacol., 2(5), 253-67 (1980).
Chemical Abstracts, 77:56546q (1972).
Chemical Abstracts, 89:135847q (1978).
Chemical Abstracts, 89:135848r (1978).
Chemical Abstracts, 68:13304f (1968).
Chemical Abstracts, 81:59867p (1974).
Chemical Abstracts, 91:83560k (1979).

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