5-Benzylpicolinic acid derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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260290R, 260295AM, 260295PA, 260295R, A61K 3144, C07D21369

Patent

active

041090004

ABSTRACT:
5-Benzy-2-pyridine carboxylic acids, in which the benzyl group is optionally substituted by one or two like or different alkyl, halo, alkoxy, nitro, amino, acetamido, hydroxy or acetoxy groups, and the corresponding amides and esters, possess dopamine .beta.-hydroxylase inhibitory properties and are useful as blood pressure lowering agents. The compounds, of which 5-(4-chlorobenzyl)-2-pyridine carboxylic acid, 5-(4-hydroxybenzyl)-2-pyridine carboxylic acid and 5-benzyl-2-pyridine carboxylic acid are typical examples, can be prepared by a number of chemical methods.

REFERENCES:
patent: 3585206 (1971-06-01), Daniels

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