5-ASA Drug delivery system

Details 5-ASA Drug delivery system 5-ASA Drug delivery system

1981-06-08

1983-02-22

Schofer, Joseph L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Ion-exchange polymer or process of preparing

521 28, 424 79, B01J 4114, A61K 3174

Patent

active

043749321

ABSTRACT:
The present invention relates to novel compounds for the prophylaxis and treatment of Inflammatory Bowel disease (IBD) via the administration of an effective amount in a suitable pharmaceutical dosage of a polymeric agent for releasing 5,5'-azobis-salicylic acid which comprises a non-degradable anionic exchange resin and the dianionic form of 5,5'-azobis-salicylic acid. The 5,5'-azobis-salicylic acid undergoes bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid.

REFERENCES:
patent: 2697059 (1954-12-01), Gustus
patent: 2721827 (1955-10-01), Gustus
patent: 2990332 (1961-06-01), Keating et al.
patent: 3143465 (1964-08-01), Keating et al.

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