5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and

Details 5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and 5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and

1988-08-19

1990-05-08

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548255, C07D21304

Patent

active

049238850

ABSTRACT:
Novel 5-Amino-1-(4-Naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs are disclosed as having antiproliferative activities useful in the treatment and control of psoriasis, inflammatory bowel syndrome, cutaneous leishmanilisis and certain types of cancer.

REFERENCES:
patent: 4227004 (1980-10-01), Wildonger
patent: 4590201 (1986-05-01), Bochis et al.
M. Bosma et al., J. Cellular Physiology, vol. 135, 317-323 (1988).
M. Berridge, Biotechnology, pp. 541-546, Jun. 1984.
M. Berridge, Scientific American, vol. 254, pp. 142-152 (1985).
E. Carofoli et al., Scientific American, vol. 263, pp. 70-78 (1985).

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