Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-09-22
1980-04-15
Raymond, Richard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
546269, 546298, A61K 3144, C07D21379
Patent
active
041984161
ABSTRACT:
5-Alkoxy-picolinic esters represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and R.sub.1 represents an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms or an acetyl group; a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an alkoxyalkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an indanyl group; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic esters, and anti-hypertensive compositions containing the 5-alkoxy-picolinic esters.
REFERENCES:
patent: 3519717 (1970-07-01), Symchowicz et al.
patent: 3737542 (1973-06-01), Carlsson et al.
patent: 3914239 (1975-10-01), Kuhnis et al.
patent: 4046553 (1977-09-01), Takahashi et al.
Beyerman, Chemical Abstracts, vol. 52 (1958), 15529f.
Deady et al., Chemical Abstracts, vol. 74 (1971), 76278v.
Asaoka Hiroyasu
Hachisu Mitsugu
Inouye Shigeharu
Itoh Osamu
Koeda Takemi
Meiji Seika Kaisha Ltd.
Raymond Richard
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