Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1977-09-30
1980-02-19
Raymond, Richard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
546 5, 546269, 546298, A61K 31445, C07D21389
Patent
active
041894898
ABSTRACT:
5-Alkoxy-picolinic acids and the salts and the esters thereof represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom; a calcium atom; a sodium atom; a potassium atom; an aluminum atom; an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom); a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic acids and the salts and the esters thereof, and anti-hypertensive compositions containing the 5-alkoxy-picolinic acids and the salts and the esters thereof.
REFERENCES:
patent: 3291805 (1966-12-01), Ondetti et al.
patent: 3519717 (1970-07-01), Symchowicz et al.
patent: 3697531 (1972-10-01), Lesher
patent: 3876648 (1975-04-01), Haas et al.
patent: 3914239 (1975-10-01), Kuhnis et al.
patent: 4083850 (1978-04-01), Koeda et al.
Brown et al., Chem. Abst., vol. 80, 1974, parag. 26492p.
Asaoka Hiroyasu
Hachisu Mitsugu
Inouye Shigeharu
Itoh Osamu
Koeda Takemi
Meiji Seika Kaisha Ltd.
Raymond Richard
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